2026-03-05T17:58:34Z https://fra.repo.nii.ac.jp/oai

oai:fra.repo.nii.ac.jp:02008610 2025-06-16T04:21:47Z 15

Targeted Metabolite Fingerprints of Thirteen Gambierdiscus, Five Coolia and Two Fukuyoa Species Murray, J. Sam Passfield, Emillie M. F. Rhodes, Lesley L. Puddick, Jonathan Finch, Sarah C. Smith, Kirsty F. Ginkel, Roel van Mudge, Elizabeth M. Nishimura, Tomohiro 2591 西村, 朋宏 70983724 ニシムラ, トモヒロ Funaki, Hiroshi フナキ, ヒロシ フナキ, ヒロシ Adachi, Masao アダチ, マサオ アダチ, マサオ Prinsep, Michèle R. Harwood, D. Tim ciguatera poisoning; ciguatoxin; maitotoxin; bioactive; mass spectrometry; benthic dinoflagellate; toxicity The genus Gambierdiscus produces an array of bioactive hydrophilic and lipophilic secondary metabolites that range in mode of action and toxicity. In this study, the metabolite fingerprint was mapped for thirteen Gambierdiscus, five Coolia and two Fukuyoa species (34 isolates) by assessing the production of 56 characterised secondary metabolites. Gambierdiscus polynesiensis was the only species to produce Pacific-ciguatoxin-3B (P-CTX3B), P-CTX3C, iso-P-CTX3B/C, P-CTX4A, P-CTX4B and iso-P-CTX4A/B. G. australes produced maitotoxin-1 (MTX-1) and MTX-5, G. cheloniae produced MTX-6 and G. honu produced MTX-7. Ubiquitous production of 44-methylgambierone was observed amongst all the Gambierdiscus isolates, with nine species also producing gambierone. Additional gambierone analogues, including anhydrogambierone (tentatively described herein), were also detected in all Gambierdiscus species, two Coolia and two Fukuyoa species. Gambieroxide was detected in G. lewisii and G. pacificus and gambieric acid A was detected in ten Gambierdiscus species, with G. australes (CAWD381) being the only isolate to produce gambieric acids A–D. This study has demonstrated that the isolates tested to date produce the known CTXs or MTXs, but not both, and highlighted several species that produced ‘unknown’ compounds displaying characteristics of cyclic polyethers, which will be the focus of future compound discovery efforts. journal article MDPI 2024-03-02 VoR application/pdf Marine Drugs 3 22 119 1660-3397 https://fra.repo.nii.ac.jp/record/2008610/files/Murray et al. Targetted metabolite fingerprints.pdf https://fra.repo.nii.ac.jp/records/2008610 eng 10.3390/md22030119 水産技術研究所　環境・応用部門　環境保全部 （廿日市） 23343080 MDPI https://www.mdpi.com/1660-3397/22/3/119