2026-03-07T06:17:03Z https://fra.repo.nii.ac.jp/oai

oai:fra.repo.nii.ac.jp:02010872 2025-11-25T02:13:13Z 1:8:1724310835301

魚類ビタミンAの胚発生での役割解明に向けて トラフグ raldh2 のクローニング Molecular cloning of raldh2 from Takifugu rubripes Uji, Susumu 702 宇治, 督 40372049 ウジ, ススム Kurokawa, Tadahide 490 黒川, 忠英 50372032 クロカワ, タダヒデ Suzuki, Tohru 2794 鈴木, 徹 スズキ, トオル vitamin A; early development; malformation; metabolic pathway of vitamin A; raldh2 Embryonic development of organs and tissues in viviparous organisms such as mammals, particularly organs such as the central nervous system, heart and skeletons, is dependent upon vitamin A supplemented from the mother. Conversely, in fish, which are oviparous, embryogenesis is entirely dependent on nutrients stored mainly as yolk within eggs during vitellogenesis. It is therefore possible that abnormalities in seed production by broodstock may arise during embryogenesis in an aquacultural setting due to vitamin A deficiency or hypervitaminosis. The authors hypothesize that, not only is vitamin A metabolism essential to the development of mature female fish, but vitamin A transfer to the eggs is essential for healthy seed production. Here we review the role of vitamin A in mammals and fish. In addition, we describe the molecular characteristics and gene expression patterns in Takifugu rubripes retinaldehyde dehydrogenase 2 (raldh2), which converts retinal to retinoic acid, an active form of vitamin A that controls the mRNA expression of various genes involved in embryogenesis. ファイル名末尾が「er」のものは、正誤表 departmental bulletin paper 水産総合研究センター 2008-12 VoR application/pdf application/pdf 水産総合研究センター研究報告 26 41 46 Bulletin of Fisheries Research Agency AA11589591 1346-9894 https://fra.repo.nii.ac.jp/record/2010872/files/fra_k_26_41.pdf https://fra.repo.nii.ac.jp/record/2010872/files/fra_k_26_41_er.pdf https://fra.repo.nii.ac.jp/records/2010872 jpn fra_k_26_41 日本農学文献記事索引（AgriKnowledge） https://agriknowledge.affrc.go.jp/RN/2010770090 open access