| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-06-26 |
| タイトル |
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タイトル |
Targeted Metabolite Fingerprints of Thirteen Gambierdiscus, Five Coolia and Two Fukuyoa Species |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ciguatera poisoning; ciguatoxin; maitotoxin; bioactive; mass spectrometry; benthic dinoflagellate; toxicity |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Murray, J. Sam
Passfield, Emillie M. F.
Rhodes, Lesley L.
Puddick, Jonathan
Finch, Sarah C.
Smith, Kirsty F.
Ginkel, Roel van
Mudge, Elizabeth M.
西村, 朋宏
フナキ, ヒロシ
アダチ, マサオ
Prinsep, Michèle R.
Harwood, D. Tim
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The genus Gambierdiscus produces an array of bioactive hydrophilic and lipophilic secondary metabolites that range in mode of action and toxicity. In this study, the metabolite fingerprint was mapped for thirteen Gambierdiscus, five Coolia and two Fukuyoa species (34 isolates) by assessing the production of 56 characterised secondary metabolites. Gambierdiscus polynesiensis was the only species to produce Pacific-ciguatoxin-3B (P-CTX3B), P-CTX3C, iso-P-CTX3B/C, P-CTX4A, P-CTX4B and iso-P-CTX4A/B. G. australes produced maitotoxin-1 (MTX-1) and MTX-5, G. cheloniae produced MTX-6 and G. honu produced MTX-7. Ubiquitous production of 44-methylgambierone was observed amongst all the Gambierdiscus isolates, with nine species also producing gambierone. Additional gambierone analogues, including anhydrogambierone (tentatively described herein), were also detected in all Gambierdiscus species, two Coolia and two Fukuyoa species. Gambieroxide was detected in G. lewisii and G. pacificus and gambieric acid A was detected in ten Gambierdiscus species, with G. australes (CAWD381) being the only isolate to produce gambieric acids A–D. This study has demonstrated that the isolates tested to date produce the known CTXs or MTXs, but not both, and highlighted several species that produced ‘unknown’ compounds displaying characteristics of cyclic polyethers, which will be the focus of future compound discovery efforts. |
|
言語 |
en |
| 書誌情報 |
en : Marine Drugs
巻 22,
号 3,
p. 119,
発行日 2024-03-02
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| 出版者 |
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|
出版者 |
MDPI |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
1660-3397 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.3390/md22030119 |
| 情報源 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
Local |
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|
関連識別子 |
23343080 |
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|
言語 |
ja |
|
|
関連名称 |
水産技術研究所 環境・応用部門 環境保全部 （廿日市） |
| 関連サイト |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
URI |
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|
関連識別子 |
https://www.mdpi.com/1660-3397/22/3/119 |
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|
言語 |
en |
|
|
関連名称 |
MDPI |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
Murray et al. Targetted metabolite fingerprints.pdf (1.7 MB)
