{"created":"2024-10-03T01:22:13.489696+00:00","id":2010868,"links":{},"metadata":{"_buckets":{"deposit":"032fb3cb-ab72-4ea7-86d4-b8d5015fb3e8"},"_deposit":{"created_by":10,"id":"2010868","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2010868"},"status":"published"},"_oai":{"id":"oai:fra.repo.nii.ac.jp:02010868","sets":["1:8:1724310835301"]},"author_link":["654","1803"],"control_number":"2010868","item_10002_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"中性スフィンゴミエリナーゼ-セラミド経路の活性化","subitem_alternative_title_language":"ja"}]},"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12","bibliographicIssueDateType":"Issued"},"bibliographicNumberOfPages":"7","bibliographicPageEnd":"21","bibliographicPageStart":"15","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"水産総合研究センター研究報告","bibliographic_titleLang":"ja"},{"bibliographic_title":"Bulletin of  Fisheries Research Agency","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mechanism of stress-induced apoptosis in fish cultured cells and embryos has been characterized to be regulated by Mg2+-dependent neutral sphingomyelinase 1. The enzyme hydrolyzes sphingomyelin as a substrate and produces ceramide by its activation through various environmental stimuli, such as heat shock, UV irradiation, gamma-ray irradiation, and C2-ceramide treatment. Such ceramide signaling activates a pro-apoptotic caspase cascade and apoptosis characterized by DNA fragmentation, and resulted in abnormal morphogenesis in fish embryogenesis. Therefore, ceramide signaling functions as the important pro-apoptotic signal in fish development and apoptosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"水産総合研究センター","subitem_publisher_language":"ja"}]},"item_10002_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"fra_k_26_15","subitem_relation_type_select":"Local"}}]},"item_10002_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"日本農学文献記事索引（AgriKnowledge）"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://agriknowledge.affrc.go.jp/RN/2010770086","subitem_relation_type_select":"URI"}}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11589591","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-9894","subitem_source_identifier_type":"PISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yabu, Takeshi","creatorNameLang":"en","creatorNameType":"Personal"},{"creatorName":"藪, 健史","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"ヤブ, タケシ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Yabu","familyNameLang":"en"},{"familyName":"藪","familyNameLang":"ja"},{"familyName":"ヤブ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Takeshi","givenNameLang":"en"},{"givenName":"健史","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1803","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00551756","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00551756"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Yamashita, Michiaki","creatorNameLang":"en"},{"creatorName":"山下, 倫明","creatorNameLang":"ja"},{"creatorName":"ヤマシタ, ミチアキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Yamashita","familyNameLang":"en"},{"familyName":"山下","familyNameLang":"ja"},{"familyName":"ヤマシタ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Michiaki","givenNameLang":"en"},{"givenName":"倫明","givenNameLang":"ja"},{"givenName":"ミチアキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"654","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80344323","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80344323"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-02"}],"filename":"fra_k_26_15.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"url":"https://fra.repo.nii.ac.jp/record/2010868/files/fra_k_26_15.pdf"},"version_id":"cefb85a2-6c7f-4375-a3c5-d147d8d56806"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"apoptosis; heat shock; UV irradiation; gamma-ray irradiation; ceramide; neutral sphingomyelinase; caspase-3; zebrafi sh; embryo; Japanese fl ounder.","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"魚類細胞および胚におけるストレス誘導性アポトーシスの分子メカニズム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"魚類細胞および胚におけるストレス誘導性アポトーシスの分子メカニズム","subitem_title_language":"ja"},{"subitem_title":"The Molecular Mechanism of Stress-Induced Apoptosis in Fish Cells and Embryos : Activation of Neutral Sphingomyelinase-Ceramide Pathway","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"10","path":["1724310835301"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-02"},"publish_date":"2024-10-02","publish_status":"0","recid":"2010868","relation_version_is_last":true,"title":["魚類細胞および胚におけるストレス誘導性アポトーシスの分子メカニズム"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2025-03-27T07:12:06.434481+00:00"}