{"created":"2024-10-03T01:22:41.826219+00:00","id":2010874,"links":{},"metadata":{"_buckets":{"deposit":"fc0db1ee-725f-47c2-9509-0e846822d3c6"},"_deposit":{"created_by":10,"id":"2010874","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2010874"},"status":"published"},"_oai":{"id":"oai:fra.repo.nii.ac.jp:02010874","sets":["1:8:1724310835301"]},"author_link":["490"],"item_10002_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"フグゲノム情報を利用したleptinおよびagoutiの同定","subitem_alternative_title_language":"ja"}]},"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12","bibliographicIssueDateType":"Issued"},"bibliographicNumberOfPages":"9","bibliographicPageEnd":"61","bibliographicPageStart":"53","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"水産総合研究センター研究報告","bibliographic_titleLang":"ja"},{"bibliographic_title":"Bulletin of  Fisheries Research Agency","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To understand the regulation systems of appetite in fish, we identified cDNA coding for leptin and agouti family proteins in pufferfish (Takifugu rubripes ). The Takifugu leptin was found using genomic synteny around the human leptin gene as a first non-mammalian leptin gene. The Takifugu leptin mRNA was expressed in the liver that contained abundant lipids. In addition, the homologues to Takifugu leptin for some fish and amphibians were found in the databanks. The phylogenetic analysis shows rapid rates of molecular divergence among leptins from different vertebrate classes. Takifugu has four types of agouti-family genes (AGRP1, AGRP2, ASIP1 and ASIP2 ). The Takifugu ASIP1 expression level was about five times higher in the white ventral skin than in the black dorsal skin. This indicates that the Takifugu ASIP1 functions to retain the dorsal-ventral pigmentation pattern like to mammalian ASIP. On the other hand, ASIP2, AGRP1 and AGRP2 mRNA expression were detected in various organs in Takifugu . Therefore, the physiological functions of melanocortins and agouti-family proteins seem to be more complex in fish than in mammals.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"水産総合研究センター","subitem_publisher_language":"ja"}]},"item_10002_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"fra_k_26_53","subitem_relation_type_select":"Local"}}]},"item_10002_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"日本農学文献記事索引（AgriKnowledge）"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://agriknowledge.affrc.go.jp/RN/2010770092","subitem_relation_type_select":"URI"}}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11589591","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-9894","subitem_source_identifier_type":"PISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kurokawa, Tadahide","creatorNameLang":"en","creatorNameType":"Personal"},{"creatorName":"黒川, 忠英","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"クロカワ, タダヒデ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"}],"familyNames":[{"familyName":"Kurokawa","familyNameLang":"en"},{"familyName":"黒川","familyNameLang":"ja"},{"familyName":"クロカワ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Tadahide","givenNameLang":"en"},{"givenName":"忠英","givenNameLang":"ja"},{"givenName":"タダヒデ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"490","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50372032","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50372032"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-02"}],"filename":"fra_k_26_53.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"url":"https://fra.repo.nii.ac.jp/record/2010874/files/fra_k_26_53.pdf"},"version_id":"0c98d041-8640-4f4f-9582-4f4867301266"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"leptin; agouti; AGRP; Takifugu","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"魚類の食欲を制御する分子機構を探る","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"魚類の食欲を制御する分子機構を探る","subitem_title_language":"ja"},{"subitem_title":"Appetite control systems in fish","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"10","path":["1724310835301"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-02"},"publish_date":"2024-10-02","publish_status":"0","recid":"2010874","relation_version_is_last":true,"title":["魚類の食欲を制御する分子機構を探る"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-11-01T01:58:06.220478+00:00"}