{"created":"2024-10-15T04:58:16.346399+00:00","id":2011669,"links":{},"metadata":{"_buckets":{"deposit":"858b3a69-b24b-4813-a4bb-82f5f319c801"},"_deposit":{"created_by":10,"id":"2011669","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2011669"},"status":"published"},"_oai":{"id":"oai:fra.repo.nii.ac.jp:02011669","sets":["1:6:1724312743637"]},"author_link":["2910"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicNumberOfPages":"7","bibliographicPageEnd":"189","bibliographicPageStart":"183","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"水産大学校研究報告","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of National Fisheries University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A peptide having the potent angiotensin I -converting enzyme (ACE) inhibitory activity was separated from Porphyra yezoensis protein hydrolysate by chromatographic analyses such as ion-exchange, gel-filtration and HPLC. The most active fraction (SP-I) obtained by SP-Sephadex C-25 chromatography provided 50% inhibition against ACE activity at 72 ug / ml reaction mixture concentration. Oral administration of the SP- I fraction (200mg/kg of body weight) spontaneously hypertensive rat showed a hypotensive effect. The SP- I fraction was further separated into the peptides using ODS HPLC. Among these peptides, an active peptide was obtained, and its primary structure was Ala-Val-Gly-Pro ( IC50;3.12 uM). Using these active peptide analogs, Val-Gly-Pro ( IC50;26.5 uM) and Ala-Gly-Pro ( IC50;89.3 uM), which were newly synthesized, the interaction between ACE inhibitory peptides and the active site of ACE was presumed.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"水産大学校","subitem_publisher_language":"ja"},{"subitem_publisher":"National Fisheries University","subitem_publisher_language":"en"}]},"item_10002_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"fishu_k_46_183","subitem_relation_type_select":"Local"}}]},"item_10002_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"日本農学文献記事索引(agriknowledge) "}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://agriknowledge.affrc.go.jp/RN/2010572368","subitem_relation_type_select":"URI"}}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00124678","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0370-9361","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suetsuna, Kunio","creatorNameLang":"en","creatorNameType":"Organizational"},{"creatorName":"末綱, 邦男","creatorNameLang":"ja","creatorNameType":"Organizational"},{"creatorName":"スエツナ, クニオ","creatorNameLang":"ja-Kana","creatorNameType":"Organizational"}],"familyNames":[{"familyName":"Suetsuna","familyNameLang":"en"},{"familyName":"末綱","familyNameLang":"ja"},{"familyName":"スエツナ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Kunio","givenNameLang":"en"},{"givenName":"邦男","givenNameLang":"ja"},{"givenName":"クニオ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2910","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"魚介類由来の生理活性ペプチドに関する研究(3) 海苔由来テトラペプチドAla-Val-Gly-Proの分離精製とアンジオテンシンI変換酵素との相互作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"魚介類由来の生理活性ペプチドに関する研究(3) 海苔由来テトラペプチドAla-Val-Gly-Proの分離精製とアンジオテンシンI変換酵素との相互作用","subitem_title_language":"ja"},{"subitem_title":"Studies on biological active peptide derived from fish and shellfish - 3 Separation and purification of Ala-Val-Gly-Pro derived from Porphyra yezoensis and its interaction with angiotensin 1 -converting enzyme","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"10","path":["1724312743637"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-11"},"publish_date":"2024-10-11","publish_status":"0","recid":"2011669","relation_version_is_last":true,"title":["魚介類由来の生理活性ペプチドに関する研究(3) 海苔由来テトラペプチドAla-Val-Gly-Proの分離精製とアンジオテンシンI変換酵素との相互作用"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2025-07-16T02:08:06.884161+00:00"}