WEKO3
アイテム
Evidence for sult1st6y as a Major Candidate Sex-Determining Gene in Pacific Bluefin Tuna
https://fra.repo.nii.ac.jp/records/2015896
https://fra.repo.nii.ac.jp/records/20158966135d0a2-bb13-4035-b8db-bfa040e54cab
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
25331001_post_print.pdf (973 KB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2026-01-07 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Evidence for sult1st6y as a Major Candidate Sex-Determining Gene in Pacific Bluefin Tuna | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Pacific bluefin tuna; Sex-determining gene; sult1st6y; Sulfotransferase | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | metadata only access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||||
| 著者 |
林田, 貴雄
× 林田, 貴雄
WEKO
1004
× 相馬, 智史× 風藤, 行紀× 中村, 洋路 |
|||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Introduction: The Y chromosome-linked gene sult1st6y (a homolog of the estrogen sulfotransferase gene) has recently been identified in Thunnus, a genus characterized by an XX/XY sex determination system. This study examined whether sult1st6y is a sex-determining gene in bluefin tuna (Thunnus orientalis). Methods: The expression of sult1st6y was examined using polymerase chain reaction analyses and in situ hybridization. Sult1st6y expression in masculinized XX testes produced by aromatase inhibitor administration and the expression profile of the sult1st6y mutant, which was produced using CRISPR/Cas9, were examined. Results:Sult1st6y was specifically expressed in XY gonads during sex differentiation. The onset of sult1st6y expression preceded that of other genes promoting sex differentiation. Sult1st6y expression was not detected in masculinized XX testes, indicating that gonads can differentiate into testes without sult1st6y if estrogens are depleted. The Sult1st6y mutant XY gonad showed a gene expression pattern similar to that of wild-type XX gonads. Conclusion: Our results collectively suggest that sult1st6y is at the top of the molecular cascade that regulates gonadal sex differentiation. Sult1st6y may trigger testicular differentiation by deactivating estrogens, although its biochemical activity should be examined. This study provides evidence that sult1st6y is a major candidate sex-determining gene in tuna. | |||||||||||
| 言語 | en | |||||||||||
| 書誌情報 |
en : Sexual Development 巻 20, 号 1-6, p. 1-13, ページ数 13, 発行日 2025-11-29 |
|||||||||||
| 出版者 | ||||||||||||
| 出版者 | Karger Publisher | |||||||||||
| 言語 | en | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 1661-5425 | |||||||||||
| 書誌レコードID | ||||||||||||
| 識別子タイプ | EISSN | |||||||||||
| 関連識別子 | 1661-5433 | |||||||||||
| PubMed番号 | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 41321005 | |||||||||||
| 言語 | en | |||||||||||
| 関連名称 | PubMed | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1159/000549624 | |||||||||||
| 言語 | en | |||||||||||
| 関連名称 | Sexual Development | |||||||||||
| 情報源 | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | Local | |||||||||||
| 関連識別子 | 25331001 | |||||||||||
| 言語 | ja | |||||||||||
| 関連名称 | 水産技術研究所 養殖部門 まぐろ養殖部 | |||||||||||
| 関連サイト | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1159/000549624 | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | AO | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||||||
