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  1. 水産研究・教育機構出版物
  2. 水産研究・教育機構研究報告
  3. 第53号

Omics analysis of red seabream (Pagrus major) fed a soybean meal-based diet

https://doi.org/10.57348/0002016032
https://doi.org/10.57348/0002016032
4dfa861c-1bfa-4114-bdfd-ddc4d3780bd8
名前 / ファイル ライセンス アクション
fra_k_53_37.pdf fra_k_53_37.pdf (1004.6 KB)
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アイテムタイプ 紀要論文 / Departmental Bulletin Paper(1)
公開日 2026-04-01
タイトル
タイトル Omics analysis of red seabream (Pagrus major) fed a soybean meal-based diet
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Pagrus major; transcriptome; metabolome; soybean meal
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
ID登録
ID登録 10.57348/0002016032
ID登録タイプ JaLC
著者 吉永, 葉月

× 吉永, 葉月

WEKO 1005
e-Rad 40830154

en Yoshinaga, Hazuki(Organizational)

ja 吉永, 葉月(Organizational)

ja-Kana ヨシナガ, ハヅキ(Organizational)

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安池, 元重

× 安池, 元重

WEKO 871
e-Rad 20604820

en Yasuike, Motoshige(Organizational)

ja 安池, 元重(Organizational)

ja-Kana ヤスイケ, モトシゲ(Organizational)

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馬久地, みゆき

× 馬久地, みゆき

WEKO 811
e-Rad 40594007

en Mekuchi, Miyuki(Organizational)

ja 馬久地, みゆき(Organizational)

ja-Kana メクチ, ミユキ(Organizational)

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相馬, 智史

× 相馬, 智史

WEKO 919
e-Rad 80758657

en Soma, Satoshi(Organizational)

ja 相馬, 智史(Organizational)

ja-Kana ソウマ, サトシ(Organizational)

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山本, 剛史

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WEKO 661
e-Rad 60372033

en Yamamoto, Takeshi(Organizational)

ja 山本, 剛史(Organizational)

ja-Kana ヤマモト, タケシ(Organizational)

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村下, 幸司

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WEKO 293
e-Rad 60597649
ORCID 0000-0003-4032-1426

en Murashita, Koji(Organizational)

ja 村下, 幸司(Organizational)

ja-Kana ムラシタ, コウジ(Organizational)

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松成, 宏之

× 松成, 宏之

WEKO 313
e-Rad 00524729

en Matsunari, Hiroyuki(Organizational)

ja 松成, 宏之(Organizational)

ja-Kana マツナリ, ヒロユキ(Organizational)

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奥, 宏海

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WEKO 384
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en Oku, Hiromi(Organizational)

ja 奥, 宏海(Organizational)

ja-Kana オク, ヒロミ(Organizational)

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古板, 博文

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e-Rad 60372041

en Furuita, Hirofumi(Organizational)

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ja-Kana フルイタ, ヒロフミ(Organizational)

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抄録
内容記述タイプ Abstract
内容記述 In response to the increasing demand for seafood, aquaculture production has been expanding worldwide in recent years. On the other hand, the high demand and unstable supply of fishmeal (FM) has made feed manufacturers difficult to use FM as the main ingredient in aquaculture feeds. Soybean meal (SBM) is one of the most promising substitutes for FM in aquaculture feeds because of its economic advantages and nutritional properties. Although SBM has a relatively high protein content and balanced amino acid composition, it has been reported that feeding of a large amount of SBM has adverse effects on the physiology and growth of fish. To facilitate the development of more effective aquaculture feeds containing SBM, it is required to elucidate the effects of dietary SBM on fish nutritional metabolism in detail. In this study, comprehensive approaches, i.e., transcriptomics and metabolomics analyses, were employed to investigate the effects of SBM on nutritional metabolism in red seabream (Pagrus major). Red seabream fingerlings were fed an SBM-based diet (SBMD) and FM-based control diet (FMD) for eight weeks and the hepatopancreas collected at 2, 4, and 8 weeks were used for transcriptome analysis. Growth retardation, and several abnormal physiological conditions such as lower serum cholesterol content and tissue degeneration in the distal intestine, were observed in the SBMD group. Transcriptome analysis (RNA-Seq) identified differentially expressed genes between the SBMD and FMD groups and showed increases in the expression levels of genes involved in the terpenoid and steroid biosynthesis pathways in the former group, suggesting that hepatic cholesterol biosynthesis was up-regulated in the SBMD group. The hepatopancreas of fish fed each diet for 8 weeks was also subjected to metabolome analysis and the results, coupled with the transcriptome analysis, suggest that SBMD affects the glutathione and glycine metabolism. Additionally, transcriptome of the distal intestine at 8 weeks revealed the changes in the expression levels of genes related to the cell cycle control and cholesterol metabolism. This study provides valuable information that enhances the understanding of the effects of dietary SBM on red seabream metabolism, which will lead to the development of a novel technology that relieves the abnormal physiological conditions. Findings obtained from omics analysis could be used to identify the indices of negative effects caused by respective alternative ingredients and thereby lead to the improvement of the quality of future aquaculture feeds.
言語 en
書誌情報 ja : 水産研究・教育機構研究報告
en : Bulletin of Japan Fisheries Research and Education Agency

巻 53, p. 37-44, ページ数 8, 発行日 2026-03-25
出版者
出版者 水産研究・教育機構
言語 ja
出版者
出版者 Japan Fisheries Research and Education Agency
言語 en
ISSN
収録物識別子タイプ PISSN
収録物識別子 2758-3953
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12767505
情報源
識別子タイプ Local
関連識別子 fra_k_53_37
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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