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Transcriptome characterization of gonadal sex differentiation in Pacific bluefin tuna, Thunnus orientalis (Temminck et Schlegel)
https://fra.repo.nii.ac.jp/records/2000067
https://fra.repo.nii.ac.jp/records/2000067f4a09108-99cb-4d5f-a95e-f68904baafaf
| 名前 / ファイル | ライセンス | アクション |
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23331001.pdf (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2024-01-12 | |||||||||||
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| タイトル | Transcriptome characterization of gonadal sex differentiation in Pacific bluefin tuna, Thunnus orientalis (Temminck et Schlegel) | |||||||||||
| 言語 | en | |||||||||||
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| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
林田, 貴雄
× 林田, 貴雄
WEKO
1004
× 相馬, 智史× 中村, 洋路× 樋口, 健太郎× 風藤, 行紀× 玄, 浩一郎 |
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Tunas (genus Thunnus) are one of the most ecologically and commercially important fish worldwide. To establish a biological basis for reproduction in this globally essential species, we have recently studied crucial reproductive aspects of the Pacific bluefin tuna (T. orientalis; PBT), as a model of tuna species, based on our closed-cycle aquaculture technology. In this study, we clarified the global expression profile of the genes regulating gonadal sex differentiation in PBT, as this developmental process is vital to sexual reproduction. Based on the results of our comparative (RNA-sequencing) and temporal (qRT-PCR) transcriptome analyses using the updated genome dataset, we propose the molecular mechanisms of gonadal sex differentiation in PBT. In female gonads, foxl2 and cyp19a1a (coding aromatase) are expressed at the onset of sex differentiation. Active aromatase-mediated estrogen biosynthesis, which includes positive regulation of cyp19a1a expression by Foxl2, induces ovarian differentiation. By contrast, dmrt1 and gsdf are upregulated in differentiating male gonads lacking active estrogen synthesis. Dmrt1 and Gsdf would mainly promote testicular differentiation. Furthermore, androgen biosynthesis is upregulated in differentiating male gonad. Endogenous androgens may also be vital to testicular differentiation. This study provides the first comprehensive data clarifying the molecular basis for gonadal sex differentiation in tunas. | |||||||||||
| 言語 | en | |||||||||||
| 書誌情報 |
en : Scientific Reports 巻 13, 号 13867, 発行日 2023-08-24 |
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| 出版者 | ||||||||||||
| 出版者 | Nature Research | |||||||||||
| 言語 | en | |||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2045-2322 | |||||||||||
| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1038/s41598-023-40914-y | |||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | Local | |||||||||||
| 関連識別子 | 23331001 | |||||||||||
| 言語 | ja | |||||||||||
| 関連名称 | 水産資源研究所 養殖部門 まぐろ養殖部 | |||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://www.nature.com/articles/s41598-023-40914-y | |||||||||||
| 言語 | en | |||||||||||
| 関連名称 | Springer Nature : scientific reports | |||||||||||
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| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
