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Selenoneine is methylated in the bodies of mice and then excreted in urine as Se-methylselenoneine
https://fra.repo.nii.ac.jp/records/2000078
https://fra.repo.nii.ac.jp/records/2000078ef965927-ba79-475f-bddf-1cb6fe7ba08f
| 名前 / ファイル | ライセンス | アクション |
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Seko et al. Seleneine is methylatedin the bodies of mice.pdf (816 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2024-01-19 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Selenoneine is methylated in the bodies of mice and then excreted in urine as Se-methylselenoneine | |||||||||||
| 言語 | en | |||||||||||
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| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Selenium; Erythrocyte; Urine methylation; Isotope | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
世古, 卓也
× 世古, 卓也× 内田, 肇× 佐藤, 洋子× 今村, 伸太朗× 石原, 賢司
WEKO
625
× 山下, 由美子× 山下, 倫明 |
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Oral intake of purified selenoneine and seafoods has been reported to result in selenoneine accumulation in erythrocytes in mice and human. In addition, Se-methylselenoneine was suggested to be produced as a metabolite of selenoneine in the urine and whole blood of humans. In order to confirm the molecular mechanism of production of Se-methylselenoneine, a stable isotope (Se-76) labeled selenoneine was biosynthesized using genetically modified fission yeast and administered to mice. The Se-76-labeled Se-methylselenoneine was detected in urine but Se-78 and Se-80-labeled Se-methylselenoneine arising from natural isotopes of Se was hardly detected. These results suggest that Se-methylselenoneine was a metabolite and the excreted form of selenoneine. The methylation of selenoneine in mice administered selenoneine continuously was evaluated by the analyses of organs using an online liquid chromatograph system with an inductively coupled plasma mass spectrometer (LC-ICP-MS). These experiments indicate that selenoneine is methylated in the liver and (or) kidneys. | |||||||||||
| 言語 | en | |||||||||||
| 書誌情報 |
en : Biological Trace Element Research 発行日 2023-11-07 |
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| 出版者 | Springer Nature | |||||||||||
| 言語 | en | |||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 0163-4984 | |||||||||||
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| 識別子タイプ | EISSN | |||||||||||
| 関連識別子 | 1559-0720 | |||||||||||
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| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1007/s12011-023-03936-1 | |||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | Local | |||||||||||
| 関連識別子 | 23344013 | |||||||||||
| 言語 | ja | |||||||||||
| 関連名称 | 水産技術研究所 環境・応用部門 水産物応用開発部 | |||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://link.springer.com/article/10.1007/s12011-023-03936-1 | |||||||||||
| 言語 | en | |||||||||||
| 関連名称 | SPRINGER LINK：Biological Trace Element Research | |||||||||||
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| 出版タイプ | AO | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||||||
