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魚類におけるビタミンKの分布と生理機能に関する研究
https://fra.repo.nii.ac.jp/records/2010836
https://fra.repo.nii.ac.jp/records/2010836eafe4e99-feb1-4b7a-8170-82aa1306c13c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fra_k_18_1.pdf (7.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2024-10-02 | |||||
| タイトル | ||||||
| タイトル | 魚類におけるビタミンKの分布と生理機能に関する研究 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Studies on the Distribution and Physiological Function of Vitamin K in Fish | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | phylloquinone; menaquinone; tissue distribution; vitamin K deficiency | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
宇田川, 美穂
× 宇田川, 美穂 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Basic information on the distribution and role of vitamin K in fish was studied in relation to dietary intake. Chapter 1 describes the concentrations of phylloquinone (PK) and menaquinones (MKs) in various tissues of wild and cultured fishes as the results of analysis based on the HPLC method. The major vitamin K in wild pelagic fish was PK, and the stomach and intestinal contents of pelagic fish showed much higher levels of PK than MK-4. Demersal fish contained relatively large amounts of MK-4 and PK but only small amounts of long chained MKs. In demersal fish, the contents of the gastrointestinal tracts were rich in MK-long chains. However, a discrepancy between the composition pattern of vitamin K in the tissues and contents of the gastrointestinal tract was observed. Cultured fish fed a menadione (MD) supplemented feed were rich in MK-4, which indicates that MD was converted to MK-4 in the body. From these results, it was concluded that either PK or MK-4 deposited in the body originates from their food and stored mainly in the liver, and the different forms of vitamin K are absorbed and/or accumulated in the tissues based on different physiological pathways. In Chapter 2, the contents of vitamin K in the plasma and tissues (kidney, liver and gonad) of fish fed diets supplemented with different vitamin K groups were determined. The PK rich diet raised the PK concentration in the plasma and the tissues much higher than the diets supplemented with short and/or long chain MKs. This indicates that PK is more easily accumulated into the body of fish than the MK homologues. Chapter 3 describes the effect of different dosages of vitamin K, either as PK or menadione sodium bisulfite （MSB）, on mortality and vertebral formation. Rearing during the spawning season with a vitamin K free diet for 11 weeks, led to most of the male fish dying. In the kidney tissue of the fish fed with a vitamin K free diet, a large number of immature erythrocytes was observed. This indicates that the female fish had been affected by hematoporia and/or hematopoiesis brought about by a deficiency in vitamin K. Diets without vitamin K caused a significantly higher incidence of bone deformity in larvae than diets supplemented with vitamin K. The maternal effect of PK deficiency on bone structures was examined in the larvae. The vitamin K deficient larvae had an abnormal vertebral formation, while PK rich larvae showed a low rate of abnormality. When fed the vitamin K deficient diet, larvae which had been fed the vitamin K rich and deficient diets had a both high rate of abnormality after 30 days, with only larvae which wrere hatched from vitamin K rich eggs and then fed on a vitamin K rich diet showed a low rate of abnormality. These results indicate that vitamin K deficiency affects bone structure both in early development and during growth. In Chapter 4, the effect of PK on the bone structure in fish was observed histochemically. The bone structure of vitamin K deficiency larvae was thin and rough after the feeding experiment for 30 days. It seemed to be connected after fine fracture of a bone surface. In contrast, in larvae fed a PK rich diet this phenomenon was not observed. These results imply that vitamin K deficiency induced bone abnormality with thin and weak structure. A vitamin K rich diet increased the osteoblast-like cells. These results imply that PK is necessary to activate the osteoblasts. It is indicated that at least part of the effects of PK on bone resorption may regulate the osteoblasts activity through an unidentified mechanism. In Chapter 5, a comprehensive discussion is given of the all results and conclusions so far described. | |||||
| 言語 | en | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 本研究では魚類におけるビタミンＫの分布を調べると共に，生体内における生理機能について考察を行った。魚類の組織中にはビタミンＫが含まれるが，その量と種類は魚種や食性により大きく異なることがわかった。生体内中のビタミンＫの中でフィロキノンは大量に見いだされたが，メナキノン類は少量であった。また，ビタミンＫの吸収率はフィロキノンで高く，メナキノン類で低くなっており，魚類のビタミンＫ利用能については両者で異なる可能性が示唆された。魚類をビタミンＫ欠乏食で飼育すると，産卵期においては死亡が多発すること，仔魚期においては骨異常個体が増加すること等も明らかになった。この増加は卵中及び餌中にビタミンＫが欠乏したときに顕著であり，骨組織が薄く脆弱になる様子が観察された。これにより，ビタミンＫは魚類にとって必須の成分であり，特に骨の発達に大きな役割を果たしていることが判明した。 | |||||
| 言語 | ja | |||||
| 書誌情報 |
ja : 水産総合研究センター研究報告 en : Bulletin of Fisheries Research Agency 巻 18, p. 1-40, ページ数 40, 発行日 2006-11 |
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| 出版者 | ||||||
| 出版者 | 水産総合研究センター | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1346-9894 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11589591 | |||||
| 情報源 | ||||||
| 識別子タイプ | Local | |||||
| 関連識別子 | fra_k_18_1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://agriknowledge.affrc.go.jp/RN/2010740413 | |||||
| 関連名称 | 日本農学文献記事索引（AgriKnowledge） | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
