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魚類における体脂肪蓄積機構の解明
https://fra.repo.nii.ac.jp/records/2010875
https://fra.repo.nii.ac.jp/records/2010875837507ce-1c72-421e-ba60-149194c8ef30
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fra_k_26_63.pdf (419.8 KB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
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| 公開日 | 2024-10-02 | |||||||||||
| タイトル | ||||||||||||
| タイトル | 魚類における体脂肪蓄積機構の解明 | |||||||||||
| 言語 | ja | |||||||||||
| タイトル | ||||||||||||
| タイトル | Molecular and cellular mechanisms of body lipid accumulation in fish | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | lipid metabolism; lipid accumulation; gene; adipocyte; cell culture | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
奥, 宏海
× 奥, 宏海
WEKO
384
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Lipid is a main component of fish body, which affects flesh quality of cultured fish. In lipid accumulation process in fish body, the activation of various adipogenic genes and the enlargement of lipid storing tissues are postulated to be involved. In this study, we investigated the molecular and cellular aspects of body lipid accumulation process in red sea bream Pagrus major . Firstly, to investigate molecular mechanism of lipid accumulation in fish, various adipogenic genes including lipoprotein lipase (LPL1, LPL2), fatty acid synthetase (FAS) and fatty acid desaturase (d6DES, SCDa, SCDb) were characterized in red sea bream. The expression of identified adipogenic genes were, different from those of mammals, detected in various tissues including adipose tissue, hepatopancreas and muscle in red sea bream, suggesting the mechanism of body lipid deposition in fish contains different features from that in mammals. Subsequently, to investigate the cellular aspects of lipid accumulation in fish, the differentiation process of adipocyte, a main site of lipid storage, was analyzed in vitro by using primary culture system. In cultured red sea bream adipocytes, the differentiation was enhanced by insulin and the adipogenic gene expression including LPL, FAS, d6DES were activated in differentiation-dependent manner. Furthermore, their expression could be modified by Br-palmitate, a non-metabolic fatty acid. These results provide information on the molecular and cellular mechanisms of lipid accumulation process in fish body. | |||||||||||
| 言語 | en | |||||||||||
| 書誌情報 |
ja : 水産総合研究センター研究報告 en : Bulletin of Fisheries Research Agency 巻 26, p. 63-68, ページ数 6, 発行日 2008-12 |
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| 出版者 | ||||||||||||
| 出版者 | 水産総合研究センター | |||||||||||
| 言語 | ja | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 1346-9894 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA11589591 | |||||||||||
| 情報源 | ||||||||||||
| 識別子タイプ | Local | |||||||||||
| 関連識別子 | fra_k_26_63 | |||||||||||
| 関連サイト | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://agriknowledge.affrc.go.jp/RN/2010770093 | |||||||||||
| 関連名称 | 日本農学文献記事索引（AgriKnowledge） | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
