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Phorbol 12-myristate 13-acetateにより惹起されるコイ栓球の凝集反応に及ぼす1-(5-Isoquinolinesulfonyl)-2-methylpiperazine,IndomethacinおよびDibutyryl Cyclic AMPの効果
https://fra.repo.nii.ac.jp/records/2011796
https://fra.repo.nii.ac.jp/records/2011796fe424470-4947-448c-831d-0c8ee5a02206
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fishu_k_53_79.pdf (589.2 KB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
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| 公開日 | 2024-10-11 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Phorbol 12-myristate 13-acetateにより惹起されるコイ栓球の凝集反応に及ぼす1-(5-Isoquinolinesulfonyl)-2-methylpiperazine,IndomethacinおよびDibutyryl Cyclic AMPの効果 | |||||||||||
| 言語 | ja | |||||||||||
| タイトル | ||||||||||||
| タイトル | Effects of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, indomethacin and dibutyryl cyclic AMP on the aggregations of carp thrombocytes induced by phorbol 12-myristate 13-acetate | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
中村, 誠
× 中村, 誠× 田中, 竜介× 近藤, 昌和
WEKO
1252
× 高橋, 幸則 |
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Aggregation of carp (Cyprinus carpio) thrombocytes in comparison with that of rat platelets induced by phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C, was studied by the whole blood method using an impedance aggregometer. Carp thrombocyte aggregation, like that of rat platelets, was triggered by PMA. The aggregating responses of carp thrombocytes induced by PMA was inhibited by 1-(5-isoquinolinesulfony1) - 2 -methylpiperazine (H-7), an inhibitor of protein kinase C. These findings suggest that the activation of protein kinase C can induce fish thrombocyte aggregation, as in the case for mammalian platelets. In addition, the effects of indomethacin, an inhibitor of cyclooxygenase, and dibutyryl cyelic AMP (db-cAMP), a cell membrane permeable cyclic AMP analogue, on the PMA-induced carp thrombocyte aggregation in comparison with that of rat platelets were examined. PMA-induced thrombocyte aggregation in carp was inhibited by indomethacin, but was not inhibited by db-cAMP. These findings show that prostaglandin (s) is involved in the mechanism of PMA-induced thrombocyte aggregation as a promoting mediator, and that cyclic AMP was not involved as an inhibitory mediator. On the contrary, PMA-induced platelet aggregation in rats was inhibited by db-cAMP, but was not inhibited by indomethacin. These findings show some differences between carp thrombocytes and rat platelets in PMA-induced aggregating mechanisms. |
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| 言語 | en | |||||||||||
| 書誌情報 |
ja : 水産大学校研究報告 en : Journal of National Fisheries University 巻 53, 号 2, p. 79-92, ページ数 14, 発行日 2005-02 |
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| 出版者 | 水産大学校 | |||||||||||
| 言語 | ja | |||||||||||
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| 出版者 | National Fisheries University | |||||||||||
| 言語 | en | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 0370-9361 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AN00124678 | |||||||||||
| 情報源 | ||||||||||||
| 識別子タイプ | Local | |||||||||||
| 関連識別子 | fishu_k_53_79 | |||||||||||
| 関連サイト | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://agriknowledge.affrc.go.jp/RN/2010721511 | |||||||||||
| 言語 | en | |||||||||||
| 関連名称 | agriknowledge | |||||||||||
