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Possible Involvement of Prostaglandin(s) and cAMP, not NO/cGMP, in the Mechanism of Carp Thrombocyte Aggregation
https://fra.repo.nii.ac.jp/records/2011863
https://fra.repo.nii.ac.jp/records/2011863de107ff7-751e-4658-ac60-d56c0971856d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fishu_k_56_91.pdf (594.1 KB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2024-10-11 | |||||
| タイトル | ||||||
| タイトル | Possible Involvement of Prostaglandin(s) and cAMP, not NO/cGMP, in the Mechanism of Carp Thrombocyte Aggregation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | carp; thrombocyte aggregation; collagen; prostaglandin; cAMP | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
松下, 映夫
× 松下, 映夫× 田中, 竜介 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aggregation of carp (Cyprinus carpio) thrombocytes, in comparison with that of rat platelets, was studied by the whole blood method using an impedance aggregometer. Carp thrombocyte aggregation, much like that of rat platelets, was triggered by collagen. Adenosine 5'-diphosphoric acid (ADP) caused rat platelet aggregation but failed to induce carp thrombocyte aggregation. While arachidonic acid effectively induced rat platelet aggregation, carp thrombocytes did not respond to the addition of arachidonic acid in 3 out of 4 cases. These findings show differences in aggregation behaviors, in response to various aggregating agents, between rat platelets and carp thrombocytes. The aggregating responses of rat platelets and carp thrombocytes induced by collagen were inhibited by indomethacin, a typical cyclooxygenase inhibitor. This raised the possibility of prostaglandin(s) involvement in the mechanism of carp thrombocyte aggregation, in a manner similar to that in rat platelets. Thrombocyte aggregation, induced in the carp by collagen, was inhibited by stable prostacyclin (PGIz) analogues (Iloprost and Beraprost), 3-isobutyl- 1 -methylxanthine (phosphodiesterase inhibitor) and N°, O2-dibutyryl adenosine 3': 5'-cyclic monophosphoric acid (db-cAMP), as similar to that of rat platelet aggregation. These results raised the possibility of cyclic AMP (cAMP) invol vement in the mechanism of carp thrombocyte aggregation, in a manner similar to that in rat platelets. Thrombocyte aggregation, induced in the carp by collagen, failed to be inhibited by sodium nitroprusside (SNP), a typical nitric oxide (NO) releaser, while SNP partially but significantly inhibited collagen-induced platelet aggregation in the rat. This suggests that NO/cyclic GMP (cGMP) does not play an inhibitory role in the mechanism of carp thrombocyte aggregation, unlike the aggregation in rat platelets. | |||||
| 言語 | en | |||||
| 書誌情報 |
ja : 水産大学校研究報告 en : Journal of National Fisheries University 巻 56, 号 1, p. 91-98, ページ数 8, 発行日 2007-11 |
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| 出版者 | ||||||
| 出版者 | 水産大学校 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | National Fisheries University | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0370-9361 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00124678 | |||||
| 情報源 | ||||||
| 識別子タイプ | Local | |||||
| 関連識別子 | fishu_k_56_91 | |||||
