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Local immune responses to two stages of Ichthyophthirius multifiliis in ginbuna crucian carp.
https://fra.repo.nii.ac.jp/records/203
https://fra.repo.nii.ac.jp/records/2032db36a10-e180-4381-adc3-6e67b5d5bb26
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2023-04-18 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Local immune responses to two stages of Ichthyophthirius multifiliis in ginbuna crucian carp. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Local immune response; Parasites; Intra-fin administration; Ginbuna crucian carp | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
シオタ, コウメイ
× シオタ, コウメイ× スケダ, マサキ× Prakash, Harsha× 近藤, 昌和
WEKO
1252
× ナカニシ, テルユキ
WEKO
2382
× ナガサワ, タカヒロ× ナカオ, ミキ× ソマモト, トモノリ |
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Ichthyophthirius multifiliis is a ciliated protozoan parasite and is known to infect many freshwater teleosts. Characterizing the immune system in epithelial tissues, where the parasites penetrate and settle, is key to understanding host–parasite interactions. This study examined local immune responses in vivo to the infective stage (theront and trophont) of the parasites using intra-fin administration, which has been developed to analyze in vivo immune responses using fish fin. CD8α+ and CD4+ T-cell compositions were increased significantly in the fin cavity injected with theront or trophont antigens. The expression of GATA-3 and T-bet mRNA, which regulate differentiation of helper T-cells, was upregulated significantly in leukocytes from the trophont antigen–injected site. In contrast, the percentages of macrophages and neutrophils, which are innate immunity components, were decreased significantly in the injection sites. These results suggest that I. multifiliis antigens inhibit the migration of macrophages and neutrophils, and T-cells are the first responders to I. multifiliis. Thus, to better understand the interaction of host immunity and I. multifiliis, further studies should focus on exploring the inhibitory factors from I. multifiliis or examining innate functions of teleost T-cells. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 書誌情報 |
en : Fish & Shellfish Immunology 巻 118, p. 19-24, ページ数 6, 発行日 2021-11 |
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| 出版者 | ||||||||||||||||||
| 出版者 | Elsevier EV. | |||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 1050-4648 | |||||||||||||||||
| DOI | ||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.1016/j.fsi.2021.08.013 | |||||||||||||||||
| 情報源 | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | Local | |||||||||||||||||
| 関連識別子 | 20230410055 | |||||||||||||||||
| 情報源 | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | Local | |||||||||||||||||
| 関連識別子 | fish-u:71-055 | |||||||||||||||||
| 関連サイト | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S1050464821002357 | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 関連名称 | Elsevier : Fish & Shellfish Immunology | |||||||||||||||||
| 関連サイト | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/34450269/ | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 関連名称 | Pub Med | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | NA | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||||||||||
