WEKO3
アイテム
Feedback regulation and coordination of the main metabolism for bacterial growth and metabolic engineering for amino acid fermentation
https://fra.repo.nii.ac.jp/records/255
https://fra.repo.nii.ac.jp/records/255f431c21d-b727-4e7d-ab8b-be5994fc78ca
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Suzuki and Matsuoka Feedback regulation and coordination.pdf (22.6 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-04-28 | |||||
| タイトル | ||||||
| タイトル | Feedback regulation and coordination of the main metabolism for bacterial growth and metabolic engineering for amino acid fermentation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
シミズ, カズユキ
× シミズ, カズユキ× 松岡, 結 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Living organisms such as bacteria are often exposed to continuous changes in the nutrient availability in nature. Therefore, bacteria must constantly monitor the environmental condition, and adjust the metabolism quickly adapting to the change in the growth condition. For this, bacteria must orchestrate (coordinate and integrate) the complex and dynamically changing information on the environmental condition. In particular, the central carbon metabolism (CCM), monomer synthesis, and macromolecular synthesis must be coordinately regulated for the efficient growth. It is a grand challenge in bioscience, biotechnology, and synthetic biology to understand how living organisms coordinate the metabolic regulation systems. Here, we consider the integrated sensing of carbon sources by the phosphotransferase system (PTS), and the feed-forward/feedback regulation systems incorporated in the CCM in relation to the pool sizes of flux-sensing metabolites and αketoacids. We also consider the metabolic regulation of amino acid biosynthesis (as well as purine and pyrimidine biosyntheses) paying attention to the feedback control systems consisting of (fast) enzyme level regulation with (slow) transcriptional regulation. The metabolic engineering for the efficient amino acid production by bacteria such as Escherichia coli and Corynebacterium glutamicum is also discussed (in relation to the regulation mechanisms). The amino acid synthesis is important for determining the rate of ribosome biosynthesis. Thus, the growth rate control (growth law) is further discussed on the relationship between (p)ppGpp level and the ribosomal protein synthesis. |
|||||
| 書誌情報 |
en : Biotechnology Advances 巻 55, p. 107887, 発行日 2022 |
|||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0734-9750 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.biotechadv.2021.107887 | |||||
| 情報源 | ||||||
| 関連名称 | 20230410054 | |||||
| 情報源 | ||||||
| 関連名称 | fish-u:71-054 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.biotechadv.2021.107887 | |||||
| 関連名称 | Biotechnology Advances | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://europepmc.org/article/MED/34921951 | |||||
| 関連名称 | Europe PMC | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://jglobal.jst.go.jp/en/detail?JGLOBAL_ID=202202261925011439 | |||||
| 関連名称 | J-GROBAL | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
