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魚類の初期発生期におけるサイトカイン遺伝子群の機能を探る
https://fra.repo.nii.ac.jp/records/2010873
https://fra.repo.nii.ac.jp/records/20108738bf2ee3f-34f9-43ba-b387-485fa13c86da
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fra_k_26_47.pdf (1.4 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
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| 公開日 | 2024-10-02 | |||||||||||
| タイトル | ||||||||||||
| タイトル | 魚類の初期発生期におけるサイトカイン遺伝子群の機能を探る | |||||||||||
| 言語 | ja | |||||||||||
| タイトル | ||||||||||||
| タイトル | Expression and function of cytokine genes in the early development of fish | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | cytokine; Macrophage migration inhibitory factor (MIF); early development; zebrafish; morpholino | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
吉浦, 康寿
× 吉浦, 康寿× 乙竹, 充× 伊藤, かな子
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Cytokines are a group of proteins that are involved in a variety of immunological and inflammatory reactions. Recently, it has been reported that cytokine genes also play an important role during development in mammals. In fish, however little is known about the role of immune-related genes during embryogenesis. Here, we report the expression and function of some cytokines during embryonic development in zebrafish. In RT-PCR analysis, the expression of three cytokines (MIF, IL-1 β and TNF- α 2) was detected before the development of the immune system in zebrafish embryos. Moreover, to elucidate the function of MIF during embryonic development in fish, we examined expression patterns and function of the zebrafish MIF gene using antisense morpholino-mediated knockdown (morpholino oligonucleotide-MO). In whole-mount in situ hybridization analysis, zebrafish MIF mRNA was detected in developing eyes, tectum, branchial arches, pectoral fi n buds, liver and gut. MIF-MO-injected embryos (morphants) displayed malformed eyes, abnormal swelling in the tectum and fourth ventricle region, and undeveloped jaw cartilage and pectoral fi ns. An increased number of apoptotic cells in the eye and neural tissues were observed in MIF morphants. These results suggest that MIF is essential for normal embryonic development even at the level of teleost. | |||||||||||
| 言語 | en | |||||||||||
| 書誌情報 |
ja : 水産総合研究センター研究報告 en : Bulletin of Fisheries Research Agency 巻 26, p. 47-52, ページ数 6, 発行日 2008-12 |
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| 出版者 | ||||||||||||
| 出版者 | 水産総合研究センター | |||||||||||
| 言語 | ja | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 1346-9894 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA11589591 | |||||||||||
| 情報源 | ||||||||||||
| 識別子タイプ | Local | |||||||||||
| 関連識別子 | fra_k_26_47 | |||||||||||
| 関連サイト | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://agriknowledge.affrc.go.jp/RN/2010770091 | |||||||||||
| 関連名称 | 日本農学文献記事索引（AgriKnowledge） | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
